Phenotypic Characterization of Insulin-Resistant and Insulin-Sensitive Obesity
نویسندگان
چکیده
منابع مشابه
Insulin-sensitive obesity.
The association between obesity and impaired insulin sensitivity has long been recognized, although a subgroup of obese individuals seems to be protected from insulin resistance. In this study, we systematically studied differences in adipose tissue biology between insulin-sensitive (IS) and insulin-resistant (IR) individuals with morbid obesity. On the basis of glucose infusion rate during eug...
متن کاملMonomeric Tartrate Resistant Acid Phosphatase Induces Insulin Sensitive Obesity
BACKGROUND Obesity is associated with macrophage infiltration of adipose tissue, which may link adipose inflammation to insulin resistance. However, the impact of inflammatory cells in the pathophysiology of obesity remains unclear. Tartrate resistant acid phosphatase (TRAP) is an enzyme expressed by subsets of macrophages and osteoclasts that exists either as an enzymatically inactive monomer ...
متن کاملChildhood obesity and insulin-resistant syndrome.
Childhood obesity has become a national concern, health threat, and is increasing at an alarming rate. Obesity is associated with many comorbidities that last into adulthood. Insulin-resistant syndrome (IRS) is developing in growing numbers of obese children. Pediatric nurses play a unique and important role in identifying which children are at risk for obesity and IRS. This article gives curre...
متن کاملInsulin signaling in primary adipocytes in insulin sensitive and insulin resistant states
Increasing numbers of people world-wide develops the disease type 2 diabetes. Development of type 2 diabetes is characterized by a shift from an insulin sensitive state to an insulin resistant state in peripheral insulin responding organs, which originates from the development of insulin resistance in the adipose tissue. Insulin resistance in combination with reduced pancreatic insulin secretio...
متن کاملZataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats
Objective(s):In insulin resistance, the insulin action in liver, muscles and adipocytes decreases and result in hyperglycemia, dyslipidemia and hyperinsulinemia. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2015
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2015-2712